Supplementary Table 2. Conservation scores (ConSurf) of G6PD variants. Based on the scores obtained from this tool, 28 variants received the highest score of 9, followed by 12 variants with a score of 8 while no variant received the lowest scores of 1 or 2. Variant Protein Consurf Variant Protein Consurf c.130G>A p.Ala44Thr 8 c.921G>C p.Gln307His 9 c.148C>T p.Pro50Ser 9 c.962G>T p.Gly321Val 6 c.152C>T p.Thr51Ile 8 c.962G>A p.Gly321Glu 6 c179T>C p.Leu60Pro 4 c.1006A>G p.Thr336Ala 9 c.185C>A p.Pro62His 5 c.1052G>T p.Gly351Val 7 C.224T>C p.Leu75Pro 3 c.1057C>T p.Pro353Ser 9 c.404A>C p.Asn135Thr 7 c.1081G>A p.Ala361Thr 7 c.409C>T p.Leu137Phe 5 c.1138A>G p.Ile380Val 6 c.473G>A p.Cys158Tyr 4 c.1139T>C p.Ile380Thr 6 c.488G>A p.Gly163Asp 3 c.1141T>C p.Phe381Leu 8 c.497G>A p.Arg166His 9 c.1159C>T p.Arg387Cys 5 c.514C>T p.Pro172Ser 9 c.1160G>A p.Arg387His 4 c.517T>C p.Phe173Leu 8 c.1166A>G p.Glu389Gly 5 c.527A>G p.Asp176Gly 9 c.1175T>C p.Ile392Thr 7 c.536G>A p.Ser179Asn 8 c.1177C>G p.Arg393Gly 7 c.592C>T p.Arg198Cys 9 c.1178G>A p.Arg393His 7 c.592C>A p.Arg198Ser 9 c.1186C>G p.Pro396Ala 9 c.593G>C p.Arg198Pro 9 c.1187C>G p.Pro396Arg 9 c.593G>A p.Arg198His 9 c.1192G>A p.Glu398Lys 9 c.679C>T p.Arg227Trp 6 c.1220A>C p.Lys407Thr 9 c.737G>T p.Arg246Leu 9 c.1225C>T p.Pro409Ser 8 c.769C>G p.Arg257Gly 9 c.1226C>A p.Pro409Gln 8 c.770G>T p.Arg257Leu 9 c.1229G>A p.Gly410Asp 8 c.806G>A p.Cys269Tyr 6 c.1316G>C p.Arg439Pro 7 c.820G>A p.Glu274Lys 9 c.1318C>T p.Leu440phe 9 c.825G>C p.Lys275Asn 7 c.1339G>A p.Gly447Arg 9 c.826C>T p.Pro276Ser 9 c.1340G>T p.Gly447Val 9 c.844G>C p.Asp282His 5 c.1358T>A p.Val453Glu 7 c.844G>T p.Asp282Tyr 5 c.1361G>A p.Arg454His 9 c.848A>G p.Asp283Gly 5 c.1366G>C p.Asp456His 9 c.851T>C p.Val284Ala 7 c.1367A>T p.Asp456Val 8 c.853C>T p.Arg285Cys 9 c.1381G>A p.Ala461Thr 8 c.910G>T p.Val304Phe 8 c.1387C>T p.Arg463Cys 3 c.920A>C p.Gln307Pro 9 c.1463G>T p.Gly488Val 8