Volume 9, Issue 4 (Journal of Clinical and Basic Research (JCBR) 2025)
jcbr 2025, 9(4): 17-22 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Poolaie S, Mehravar F, Faghihi E, Moradi A, Sanagoo A, Jouybari L. The effect of damask rose on systolic and diastolic blood pressure in adults: A systematic review and meta-analysis of randomized controlled trials. jcbr 2025; 9 (4) :17-22
URL: http://jcbr.goums.ac.ir/article-1-533-en.html
URL: http://jcbr.goums.ac.ir/article-1-533-en.html
Saba Poolaie1 
, Fatemeh Mehravar *2 , Elham Faghihi1 , Ali Moradi1 , Akram Sanagoo3 , Leila Jouybari3
, Fatemeh Mehravar *2 , Elham Faghihi1 , Ali Moradi1 , Akram Sanagoo3 , Leila Jouybari3
1- Student Research Committee, Golestan University of Medical Sciences, Golestan, Iran
2- Ischemic Disorders Research Center, Jorjani Clinical Sciences Research Institute, Golestan University of Medical Sciences, Golestan, Iran ,Mehravar10261@yahoo.com
3- Nursing Department, Faculty of Nursing and Midwifery, Golestan University of Medical Sciences, Golestan, Iran
2- Ischemic Disorders Research Center, Jorjani Clinical Sciences Research Institute, Golestan University of Medical Sciences, Golestan, Iran ,
3- Nursing Department, Faculty of Nursing and Midwifery, Golestan University of Medical Sciences, Golestan, Iran
Abstract: (466 Views)
Background: The effect of damask rose on lowering blood pressure has been investigated, and findings suggest a potential beneficial impact on reducing both systolic and diastolic blood pressure; however, the available data are not yet conclusive. This meta-analysis was conducted to provide a more precise estimate of the effect of damask rose on systolic and diastolic blood pressure in adults.
Methods: The databases Scopus, PubMed, Web of Science Core Collection, Embase, CENTRAL, ProQuest, CINAHL, SID, and MagIran were systematically searched to identify relevant studies published prior to July 2024 that evaluated the impact of damask rose on systolic and diastolic blood pressure. From an initial yield of 678 records, five randomized controlled trials (RCTs) were deemed eligible for inclusion. The methodological quality of these trials was assessed using the Cochrane risk-of-bias tool. Where data permitted, a meta-analysis was conducted using a random-effects model in Stata software (version 11.2); otherwise, findings were summarized narratively. Continuous outcomes were pooled and expressed as standardized mean differences with 95% confidence intervals (95% CI).
Results: A total of five randomized controlled trials (RCTs), comprising a combined sample of 410 participants, were included in this meta-analysis. When comparing the intervention groups (receiving Damask rose products) with the control groups, the pooled effect size showed no statistically significant reduction in either systolic or diastolic blood pressure. For systolic blood pressure (SBP), the standardized mean difference (SMD) was -0.49 (95% confidence interval: -1.18 to 0.20, P = 0.16). For diastolic blood pressure (DBP), the SMD was -0.11 (95% CI: -0.51 to 0.28, P = 0.57). Significant and substantial heterogeneity was observed among the studies for both outcomes (SBP: I² = 88%, P < 0.01; DBP: I² = 93%, P < 0.01), indicating high inconsistency in effect sizes.
Conclusion: The administration of damask rose may not be associated with changes in systolic and diastolic blood pressure in adults. Given the paucity of available evidence, further studies are required to confirm these findings.
Methods: The databases Scopus, PubMed, Web of Science Core Collection, Embase, CENTRAL, ProQuest, CINAHL, SID, and MagIran were systematically searched to identify relevant studies published prior to July 2024 that evaluated the impact of damask rose on systolic and diastolic blood pressure. From an initial yield of 678 records, five randomized controlled trials (RCTs) were deemed eligible for inclusion. The methodological quality of these trials was assessed using the Cochrane risk-of-bias tool. Where data permitted, a meta-analysis was conducted using a random-effects model in Stata software (version 11.2); otherwise, findings were summarized narratively. Continuous outcomes were pooled and expressed as standardized mean differences with 95% confidence intervals (95% CI).
Results: A total of five randomized controlled trials (RCTs), comprising a combined sample of 410 participants, were included in this meta-analysis. When comparing the intervention groups (receiving Damask rose products) with the control groups, the pooled effect size showed no statistically significant reduction in either systolic or diastolic blood pressure. For systolic blood pressure (SBP), the standardized mean difference (SMD) was -0.49 (95% confidence interval: -1.18 to 0.20, P = 0.16). For diastolic blood pressure (DBP), the SMD was -0.11 (95% CI: -0.51 to 0.28, P = 0.57). Significant and substantial heterogeneity was observed among the studies for both outcomes (SBP: I² = 88%, P < 0.01; DBP: I² = 93%, P < 0.01), indicating high inconsistency in effect sizes.
Conclusion: The administration of damask rose may not be associated with changes in systolic and diastolic blood pressure in adults. Given the paucity of available evidence, further studies are required to confirm these findings.
References
1. Rezaei B, Hemmati MM, Khadem VK, Alinejad V. The impact of family-oriented lifestyle-based group discussion on the controlling hypertension. NMJ. 2016;14(6):535-42. [View at Publisher] [Google Scholar]
2. Sotodeh-Asl N, Neshat-Dust HT, Kalantari M, Talebi H, Khosravi, AR. Comparison of effectiveness of two methods of hope therapy and drug therapy on the quality of life in the patients with essential hypertension. J Clin Psychol. 2010;2(1):27-34. [View at Publisher] [Google Scholar]
3. Mazloomy Mahmoodabad SS, Rabeeh AA, Movahed E, Jadgal KJ, Alizadeh S. Predictive control high blood pressure in patients with hypertension based on health belief model in Kerman in 2015. TB. 2016;14(6):98-106. [View at Publisher] [Google Scholar]
4. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365(9455):217-23. [View at Publisher] [DOI] [PMID] [Google Scholar]
5. Khoshraftar RE, Ildarabadi E, Behnam VHR, Emami Moghaddam Z. The effect of peer education on the mental aspect of quality of life of elderly patients with hypertension. J North Khorasan Univ Med Sci. 2015;7(3):585-95. [View at Publisher] [Google Scholar]
6. Haghranjbar F, Shirzad M, Taghdisi MH, SaramiFooroshani GH, Ahadi H. The mediating role of subjective-wellbeing in terms of perceived stress and hypertension. Iran J Health Educ Health Promot. 2016;4(1):50-57. [View at Publisher] [DOI] [Google Scholar]
7. Mazloomy Mahmoodabad SS, Tehrani H, Gholian-Aval M, Gholami H, Nematy M. The effect of social class on the amount of salt intake in patients with hypertension. Blood Press. 2016;25(6):360-3. [View at Publisher] [DOI] [PMID] [Google Scholar]
8. Pickering TG. Why are we doing so badly with the control of hypertension? Poor compliance is only part of the story. J Clin Hypertens (Greenwich). 2001;3(3):179-82. [View at Publisher] [DOI] [PMID] [Google Scholar]
9. Lauffenburger JC, Landon JE, Fischer MA. Effect of combination therapy on adherence among US patients initiating therapy for hypertension: a cohort study. J Gen Intern Med. 2017;32(6):619-25. [View at Publisher] [DOI] [PMID] [Google Scholar]
10. Uzun S, Vural H, Uzun M, Yokusoglu M. State and trait anxiety levels before coronary angiography. J Clin Nurs. 2008;17(5):602-7. [View at Publisher] [DOI] [PMID] [Google Scholar]
11. Muzzarelli L, Force M, Sebold M. Aromatherapy and reducing preprocedural anxiety: A controlled prospective study. Gastroenterology Nursing. 2006;29(6):466-71. [View at Publisher] [DOI] [PMID] [Google Scholar]
12. Hur M-H, Lee MS, Kim C, Ernst E. Aromatherapy for treatment of hypertension: a systematic review. J Eval Clin Pract. 2012;18(1):37-41. [View at Publisher] [DOI] [PMID] [Google Scholar]
13. Mohamadinasab S, Ravari A, Mirzaei T, Sayadi AR. The effect of aromatherapy with essential rose oils on blood pressure in hypertensive patients. J Med Plants . 2019;18(72):202-14. [View at Publisher] [DOI] [Google Scholar]
14. Kim M, Kwon YJ. Effects of aroma inhalation on blood pressure, pulse, visual analog scale, and McNair scale in nursing students practicing intravenous injection at the first time. IJAST. 2010;23(2):61-68. [View at Publisher] [Google Scholar]
15. Cha JH, Lee SH, Yoo YS. Effects of aromatherapy on changes in the autonomic nervous system, aortic pulse wave velocity and aortic augmentation index in patients with essential hypertension. J Korean Acad Nurs. 2010;40(5):705-13. [View at Publisher] [DOI] [PMID] [Google Scholar]
16. Hutton B, Catala-Lopez F, Moher D. The PRISMA statement extension for systematic reviews incorporating network meta-analysis: PRISMA-NMA. Med Clin (Barc). 2016;147(6):262-6. [View at Publisher] [DOI] [PMID] [Google Scholar]
17. Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011]. London: The Cochrane Collaboration; 2011. [View at Publisher]
18. Bikmoradi A, Roshanaei GH, Moradkhani SH, Fatahi A. Impact of inhalation aromatherapy with Damask Rose (R. damascena) on stress, anxiety and hemodynamic parameters of patients undergoing coronary angiography: a single blind randomized clinical trial. J Complement Integr Med. 2022;19(3):753-61. [View at Publisher] [DOI] [PMID] [Google Scholar]
19. Tazakori Z, Babaee S, Karimollahi M, Ahmadian-Attari MM, Bayat F. The effect of oral damask rose extract on anxiety of patients undergoing coronary angiography. Journal of Health and Care. 2016;18(3):207-16. [View at Publisher] [Google Scholar]
20. Najafi S, Sajjadi M, asirzadeh A, Jeddi H. The effect of rose aromatherapy on anxiety before abdominal operation. Intern Med Today. 2020;26(2):128-41. [View at Publisher] [DOI] [Google Scholar]
21. Hashemi N, Faghih A. Effects of blended aromatherapy using lavender and damask rose oils on the hemodynamic status of nursing students. Electron J Gen Med. 2018;15(4):em40. [View at Publisher] [DOI] [PMID] [Google Scholar]
22. Setayesh L, Ashtary-Larky D, Clark CCT, Rezaei Kelishadi M, Khalili P, Bagheri R, et al. The effect of saffron supplementation on blood pressure in adults: a systematic review and dose-response meta-analysis of randomized controlled trials. Nutrients. 2021;13(8):2736. [View at Publisher] [DOI] [PMID] [Google Scholar]
23. Heydarian A, Tahvilian N, Shahinfar H, Abbas-Hashemi SA, Daryabeygi-Khotbehsara R, Aryaeian N. Effect of cardamom consumption on inflammation and blood pressure in adults: A systematic review and meta-analysis of randomized clinical trials. Food Sci Nutr. 2023;12(1):3-12. [View at Publisher] [DOI] [PMID] [Google Scholar]
24. Sahebkar A, Soranna D, Liu X, Thomopoulos C, Simental-Mendia LE, Derosa G, et al. A systematic review and meta-analysis of randomized controlled trials investigating the effects of supplementation with Nigella sativa (black seed) on blood pressure. J Hypertens. 2016;34(11):2127-35. [View at Publisher] [DOI] [PMID] [Google Scholar]
25. Hasani H, Arab A, Hadi A, Pourmasoumi M, Ghavami A, Miraghajani M. Does ginger supplementation lower blood pressure? A systematic review and meta-analysis of clinical trials. Phytother Res. 2019;33(6):1639-47. [View at Publisher] [DOI] [PMID] [Google Scholar]
26. Cheng BCY, Fu X-Q, Guo H, Li T, Wu Z-Z, Chan K, et al. The genus Rosa and arthritis: Overview on pharmacological perspectives. Pharmacol Res. 2016;114:219-34. [View at Publisher] [DOI] [PMID] [Google Scholar]
27. Boskabady MH, Vatanprast A, Parsee H, Ghasemzadeh M. Effect of aqueous-ethanolic extract from Rosa damascena on guinea pig isolated heart. Iran J Basic Med Sci. 2011;14(2):116-21. [View at Publisher] [DOI] [Google Scholar]
28. Kwon E-K, Lee D-Y, Lee H, Kim D-O, Baek N-I, Kim Y-E, et al. Flavonoids from the buds of Rosa damascena inhibit the activity of 3-hydroxy-3-methylglutaryl-coenzyme a reductase and angiotensin I-converting enzyme. J Agric Food Chem. 2010;58(2):882-6. [View at Publisher] [DOI] [PMID] [Google Scholar]
29. Afsari Sardari F, Mosleh G, Azadi A, Mohagheghzadeh A, Badr P. Traditional and Recent Evidence on Five Phytopharmaceuticals from Rosa damascena Herrm. RJP. 2019;6(3):77-84. [View at Publisher] [DOI] [Google Scholar]
30. Tavakoli A, Shirzad M, Taghavi A, Fattahi M, Ahmadian-Attari M, Mohammad Taghizadeh L, et al. Efficacy of Rose Oil Soft Capsules on Clinical Outcomes in Ulcerative Colitis: A Pilot Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. Galen Med J. 2019:8:e1307. [View at Publisher] [DOI] [PMID] [Google Scholar]
31. Haddadi M, Robat Sarpooshi H, Jaghouri E, Dehnabi A. The effect of aromatherapy with rose essential oil on apparent anxiety in patients with myocardial infarction. J Complement Integr Med. 2021;19(4):1007-12. [View at Publisher] [DOI] [PMID] [Google Scholar]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0).
